SETD7 Antikörper (C-Term)

Produktnummer ABIN2783571

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SETD7 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund, Pferd, Schwein, Kaninchen, Rind (Kuh), Zebrafisch (Danio rerio) und Meerschweinchen.Es wurde in 1 Publikation zitiert.

Kurzübersicht für SETD7 Antikörper (C-Term) (ABIN2783571)

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Schwein, Kaninchen, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SETD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SETD7 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: SETD7 Antibody - C-terminal region

Sequenz: PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against SETD7. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SETD7

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48940-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SETD7 Antikörper (ABIN2783571)

Subramanian, Jia, Kapoor-Vazirani, Powell, Collins, Sharma, Peng, Cheng, Vertino: "Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase." in: Molecular cell, Vol. 30, Issue 3, pp. 336-47, (2008) (PubMed).

Details zu SETD7

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Andere Bezeichnung: SETD7

Hintergrund:

Background Information: SETD7 is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. It is recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. It has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins.

Gene Name: SET domain containing (lysine methyltransferase) 7

Alternative Symbols: KMT7, SET7, SET9, SET7/9

Protein Name: Histone-lysine N-methyltransferase SETD7

Molekulargewicht: 41kDa

Gen-ID: 80854

NCBI Accession: NP_085151

UniProt: Q8WTS6