QPCT Antikörper (Middle Region)

Produktnummer ABIN2783489

Produktdetails anti-QPCT Antikörper

Target: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Schaf, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser QPCT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SRHLAAKMAS TPHPPGARGT SQLHGMDLLV LLDLIGAPNP TFPNFFPNSA

Homologie: Cow: 86%, Dog: 79%, Guinea Pig: 93%, Horse: 79%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 100%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against QPCT. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human QPCT

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 361 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu QPCT

Target: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Andere Bezeichnung: QPCT (QPCT Produkte)

Synonyme: GCT antikoerper, QC antikoerper, sQC antikoerper, QPCT antikoerper, 5730422A13Rik antikoerper, Qpctl1 antikoerper, RGD1562284 antikoerper, qpct antikoerper, glutaminyl-peptide cyclotransferase antikoerper, glutaminyl-peptide cyclotransferase (glutaminyl cyclase) antikoerper, glutaminyl-peptide cyclotransferase L homeolog antikoerper, QPCT antikoerper, Qpct antikoerper, M6_Spy0443 antikoerper, M5005_Spy_0416 antikoerper, M28_Spy0404 antikoerper, CJA_2408 antikoerper, CCNA_02733 antikoerper, Tsp_03182 antikoerper, qpct.L antikoerper

Hintergrund: QPCT is responsible for the biosynthesis of pyroglutamyl peptides. QPCT has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. It also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. QPCT may be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86 % identical to that of bovine glutaminyl cyclase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GCT, QC, sQC
Protein Interaction Partner: CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, NEDD8, UBC,
Protein Size: 361

Molekulargewicht: 38 kDa

Gen-ID: 25797

NCBI Accession: NM_012413, NP_036545

UniProt: Q16769