Manic Fringe Antikörper (Middle Region)

Produktnummer ABIN2783425

Der Kaninchen Polyklonal Anti-Manic Fringe-Antikörper wurde für WB validiert. Er ist geeignet, Manic Fringe in Proben von Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen und Kaninchen zu detektieren.

Kurzübersicht für Manic Fringe Antikörper (Middle Region) (ABIN2783425)

Target: Manic Fringe (MFNG) (MFNG)

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Manic Fringe Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Manic Fringe Antikörper

Bindungsspezifität: Middle Region

Sequenz: MAPWASGSRF MDTSALIRLP DDCTMGYIIE CKLGGRLQPS PLFHSHLETL

Homologie: Cow: 79%, Dog: 86%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MFNG. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MFNG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 321 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Manic Fringe

Target: Manic Fringe (MFNG) (MFNG)

Andere Bezeichnung: MFNG

Hintergrund: MFNG is one of the evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: DLL1, JAG1, NOTCH2, NOTCH1,
Protein Size: 321

Molekulargewicht: 36 kDa

Gen-ID: 4242

NCBI Accession: NM_002405, NP_002396

UniProt: O00587

Pathways: Notch Signalweg