BAG3 Antikörper (Middle Region)

Produktnummer ABIN2783302

Der Kaninchen Polyklonal anti-BAG3 Antikörper wird verwendet zum Nachweis von BAG3 in Proben von Human, Maus, Ratte, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd und Hund. Er wurde validiert für WB.

Kurzübersicht für BAG3 Antikörper (Middle Region) (ABIN2783302)

Target: BAG3 (BCL2-Associated Athanogene 3 (BAG3))

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAG3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BAG3 Antikörper

Bindungsspezifität: Middle Region

Sequenz: NVTRPAAQPS FHQAQKTHYP AQQGEYQTHQ PVYHKIQGDD WEPRPLRAAS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against BAG3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BAG3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 575 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu BAG3

Target: BAG3 (BCL2-Associated Athanogene 3 (BAG3))

Andere Bezeichnung: BAG3

Hintergrund: BAG3 inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. BAG3 has anti-apoptotic activity.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BAG-3, BIS, CAIR-1, MGC104307
Protein Interaction Partner: SF3B4, DAZAP2, ARRDC3, LITAF, MAGED1, PDE9A, HSPA8, PHLDB1, HSPB1, HSF1, STUB1, DNAJB6, AMOT, PDLIM7, MLF2, HSPB8, WBP2, UBC, MCM7, HSP90AB1, ETFA, MVP, ACLY, PSAP, PSME1, PSMD12, PSMD9, PSMD8, PSMD5, PSMD3, PSMD2, PSMC5, PSMC3, PSMC2, PSMC1, PSMB5, PSMB4
Protein Size: 575

Molekulargewicht: 61 kDa

Gen-ID: 9531

NCBI Accession: NM_004281, NP_004272

UniProt: O95817