Selenoprotein S Antikörper (Middle Region)

Produktnummer ABIN2783218

Zitiert in 3+ Publikationen. Der Kaninchen Polyklonal anti-Selenoprotein S Antikörper (ABIN2783218) detektiert spezifisch Selenoprotein S in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Hund, Rind (Kuh), Ziege, Meerschweinchen, Pferd, Kaninchen, Saccharomyces cerevisiae und Zebrafisch (Danio rerio).

Kurzübersicht für Selenoprotein S Antikörper (Middle Region) (ABIN2783218)

Target: Selenoprotein S (SELS)

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Ziege, Meerschweinchen, Pferd, Kaninchen, Saccharomyces cerevisiae, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Selenoprotein S Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Selenoprotein S Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: SELENOS Antibody - middle region

Sequenz: PDVVVKRQEA LAAARLKMQE ELNAQVEKHK EKLKQLEEEK RRQKIEMWDS

Homologie: Cow: 93%, Dog: 86%, Goat: 75%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 92%, Rat: 93%, Yeast: 90%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SELS. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SELS

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48082-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Selenoprotein S Antikörper (ABIN2783218)

Du, Liu, Huang: "Influence of SelS gene silence on beta-Mercaptoethanol-mediated endoplasmic reticulum stress and cell apoptosis in HepG2 cells." in: Biochimica et biophysica acta, Vol. 1800, Issue 5, pp. 511-7, (2010) (PubMed).

Moses, Johnson, Tømmerdal, Forsmo, Curran, Abraham, Charlesworth, Brennecke, Blangero, Austgulen: "Genetic association of preeclampsia to the inflammatory response gene SEPS1." in: American journal of obstetrics and gynecology, Vol. 198, Issue 3, pp. 336.e1-5, (2008) (PubMed).

Zeng, Du, Zhou, Huang: "Role of SelS in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells." in: Archives of biochemistry and biophysics, Vol. 478, Issue 1, pp. 1-6, (2008) (PubMed).

Details zu Selenoprotein S

Target: Selenoprotein S (SELS)

Andere Bezeichnung: SELENOS

Hintergrund:

Background Information: This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019).

Gene Name: selenoprotein S

Alternative Symbols: SELS, VIMP, ADO15, SBBI8, SEPS1, AD-015

Protein Name: selenoprotein S

Molekulargewicht: 21kDa

Gen-ID: 55829

NCBI Accession: NP_060915

UniProt: Q9BQE4

Pathways: Cellular Response to Molecule of Bacterial Origin, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom