ATRX Antikörper (C-Term)

Produktnummer ABIN2783135

Produktdetails anti-ATRX Antikörper

Target: ATRX (helicase 2, X-linked (ATRX))

Bindungsspezifität: C-Term

Reaktivität: Human, Kaninchen, Schwein, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATRX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DQSDETSEDD KKQSKKGTEE KKKPSDFKKK VIKMEQQYES SSDGTEKLPE

Homologie: Dog: 88%, Human: 100%, Pig: 93%, Rabbit: 75%

Produktmerkmale: This is a rabbit polyclonal antibody against ATRX. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ATRX

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Andere Bezeichnung: ATRX (ATRX Produkte)

Synonyme: ATR2 antikoerper, JMS antikoerper, MRXHF1 antikoerper, RAD54 antikoerper, RAD54L antikoerper, SFM1 antikoerper, SHS antikoerper, XH2 antikoerper, XNP antikoerper, ZNF-HX antikoerper, 4833408C14Rik antikoerper, AI447451 antikoerper, DXHXS6677E antikoerper, HP1-BP38 antikoerper, Hp1bp2 antikoerper, Hp1bp38 antikoerper, MRXS3 antikoerper, Rad54 antikoerper, Xnp antikoerper, atrx antikoerper, rad54 antikoerper, atrxl antikoerper, wu:fb26e12 antikoerper, wu:fb52h08 antikoerper, wu:fb72g09 antikoerper, wu:fb94e07 antikoerper, zgc:66223 antikoerper, ATRX, chromatin remodeler antikoerper, alpha thalassemia/mental retardation syndrome X-linked L homeolog antikoerper, alpha thalassemia/mental retardation syndrome X-linked homolog (human) antikoerper, ATRX antikoerper, Atrx antikoerper, atrx.L antikoerper, atrx antikoerper

Hintergrund: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Protein Interaction Partner: SUMO2, SUMO3, RAD51, H3F3A, PRKDC, PML, NBN, MRE11A, HIST1H1C, XRCC6, DAXX, SUPT16H, RAD50, HIST1H4J, HIST2H2BE, HIST1H2BL, HIST1H2AB, XRCC5, TP53, SSRP1, RPA1, RAD9A, RAD1, ZNF512B, UL82, NEK1, BLM, HIST2H3C, ZBED1, UBC, SVIL, CALM1, WRN, HIST1H3A, CBX5,
Protein Size: 1350

Molekulargewicht: 148 kDa

Gen-ID: 546