ATRX Antikörper (C-Term)

Produktnummer ABIN2783135

Der Kaninchen Polyklonal anti-ATRX Antikörper (ABIN2783135) detektiert spezifisch ATRX in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Kaninchen, Schwein und Hund.

Kurzübersicht für ATRX Antikörper (C-Term) (ABIN2783135)

Target: ATRX (helicase 2, X-linked (ATRX))

Reaktivität: Human, Kaninchen, Schwein, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATRX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ATRX Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: ATRX Antibody - C-terminal region

Sequenz: DQSDETSEDD KKQSKKGTEE KKKPSDFKKK VIKMEQQYES SSDGTEKLPE

Homologie: Dog: 88%, Human: 100%, Pig: 93%, Rabbit: 75%

Produktmerkmale: This is a rabbit polyclonal antibody against ATRX. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ATRX

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47775-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Andere Bezeichnung: ATRX

Hintergrund:

Background Information: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene Name: similar to putative DNA dependent ATPase and helicase

Alternative Symbols: JMS, XH2, XNP, MRX52, RAD54, RAD54L, ZNF-HX

Protein Name: Transcriptional regulator ATRX

Molekulargewicht: 148kDa

Gen-ID: 546

UniProt: P46100