ATRX Antikörper (C-Term)

Produktnummer ABIN2783135

Dieses Anti-ATRX-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ATRX in WB. Geeignet für Human, Kaninchen, Schwein und Hund.

Kurzübersicht für ATRX Antikörper (C-Term) (ABIN2783135)

Target: ATRX (helicase 2, X-linked (ATRX))

Reaktivität: Human, Kaninchen, Schwein, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATRX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ATRX Antikörper

Bindungsspezifität: C-Term

Sequenz: DQSDETSEDD KKQSKKGTEE KKKPSDFKKK VIKMEQQYES SSDGTEKLPE

Homologie: Dog: 88%, Human: 100%, Pig: 93%, Rabbit: 75%

Produktmerkmale: This is a rabbit polyclonal antibody against ATRX. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ATRX

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Andere Bezeichnung: ATRX

Hintergrund: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Protein Interaction Partner: SUMO2, SUMO3, RAD51, H3F3A, PRKDC, PML, NBN, MRE11A, HIST1H1C, XRCC6, DAXX, SUPT16H, RAD50, HIST1H4J, HIST2H2BE, HIST1H2BL, HIST1H2AB, XRCC5, TP53, SSRP1, RPA1, RAD9A, RAD1, ZNF512B, UL82, NEK1, BLM, HIST2H3C, ZBED1, UBC, SVIL, CALM1, WRN, HIST1H3A, CBX5,
Protein Size: 1350

Molekulargewicht: 148 kDa

Gen-ID: 546