Selenoprotein N Antikörper (C-Term)

Produktnummer ABIN2783070

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Selenoprotein N in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Rind (Kuh), Meerschweinchen, Pferd, Ratte und Schwein.

Kurzübersicht für Selenoprotein N Antikörper (C-Term) (ABIN2783070)

Target: Selenoprotein N (SELENON)

Reaktivität: Human, Maus, Rind (Kuh), Meerschweinchen, Pferd, Ratte, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Selenoprotein N Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Selenoprotein N Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: SELENON Antibody - C-terminal region

Sequenz: NYFLDITSVK PEEIESNLFS FSSTFEDPST ATYMQFLKEG LRRGLPLLQP

Homologie: Cow: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SEPN1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SEPN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47656-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Selenoprotein N

Target: Selenoprotein N (SELENON)

Andere Bezeichnung: SELENON

Hintergrund:

Background Information: This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene.

Gene Name: selenoprotein N

Alternative Symbols: RSS, CFTD, SELN, MDRS1, RSMD1, SEPN1

Protein Name: selenoprotein N

Molekulargewicht: 58kDa

Gen-ID: 57190

NCBI Accession: NP_996809

UniProt: Q9NZV5