MORF4L1 Antikörper (Middle Region)

Produktnummer ABIN2783048

Produktdetails anti-MORF4L1 Antikörper

Target: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MORF4L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PEELKPWLVD DWDLITRQKQ LFYLPAKKNV DSILEDYANY KKSRGNTDNK

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 93%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against Morf4l1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 362 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MORF4L1

Target: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Andere Bezeichnung: Morf4l1 (MORF4L1 Produkte)

Synonyme: Eaf3 antikoerper, HsT17725 antikoerper, MEAF3 antikoerper, MORFRG15 antikoerper, MRG15 antikoerper, S863-6 antikoerper, TEG-189 antikoerper, Tex189 antikoerper, mKIAA4002 antikoerper, MORF4L2 antikoerper, CG6363 antikoerper, DmMRG15 antikoerper, Dmel\\CG6363 antikoerper, Dmrg15 antikoerper, Mrg15 antikoerper, dMRG15 antikoerper, dMrg15 antikoerper, l(3)j6A3 antikoerper, zgc:92289 antikoerper, mortality factor 4 like 1 antikoerper, MORF-related gene 15 antikoerper, MRG15 antikoerper, mortality factor 4 like 1 S homeolog antikoerper, MORF4L1 antikoerper, Morf4l1 antikoerper, MRG15 antikoerper, CpipJ_CPIJ013367 antikoerper, morf4l1.S antikoerper, morf4l1 antikoerper

Hintergrund: Morf4l1 is a component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Alias Symbols: KIAA4002, MGC102415, MGC103105, MGC118047, MORFRG15, MRG15, TEG-189, Tex189, mKIAA4002
Protein Interaction Partner: Nanog, Hdac1, Phf12, Sin3b, Rb1, MRFAP1, Vezf1, Rnf2, Kdm5b, SIN3A, TLE1, PFN2,
Protein Size: 362

Molekulargewicht: 41 kDa

Gen-ID: 21761

NCBI Accession: NM_001039147, NP_001034236

UniProt: P60762

Pathways: Chromatin Binding