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MAFK Antikörper (N-Term)

MAFK Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Zebrafisch (Danio rerio), Hund, Pferd, Kaninchen, Schaf WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2783019
  • Target Alle MAFK Antikörper anzeigen
    MAFK (Transcription Factor MafK (MAFK))
    Bindungsspezifität
    • 7
    • 6
    • 6
    • 2
    N-Term
    Reaktivität
    • 26
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Zebrafisch (Danio rerio), Hund, Pferd, Kaninchen, Schaf
    Wirt
    • 24
    • 2
    Kaninchen
    Klonalität
    • 24
    • 2
    Polyklonal
    Konjugat
    • 11
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Dieser MAFK Antikörper ist unkonjugiert
    Applikation
    • 20
    • 16
    • 14
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    KEAGENAPVL SDDELVSMSV RELNQHLRGL TKEEVTRLKQ RRRTLKNRGY
    Homologie
    Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 79%, Zebrafish: 86%
    Produktmerkmale
    This is a rabbit polyclonal antibody against MAFK. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human MAFK
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  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 156 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MAFK (Transcription Factor MafK (MAFK))
    Andere Bezeichnung
    MAFK (MAFK Produkte)
    Synonyme
    NFE2U antikoerper, P18 antikoerper, AW061068 antikoerper, NF-E2 antikoerper, Nfe2u antikoerper, MAF bZIP transcription factor K antikoerper, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) antikoerper, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K antikoerper, Mafk antikoerper, MAFK antikoerper, mafk antikoerper
    Hintergrund
    The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2. NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, PBGD and FECH. NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG, or MafK) and p45. Both subunits are members of the activator protein-1 superfamily of bZIP proteins. Maf homodimers suppress transcription at NFE2 sites.The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD, MIM 176000) and ferrochelatase (FECH, MIM 177000). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM].
    Alias Symbols: FLJ32205, MGC71717, NFE2U, P18
    Protein Interaction Partner: NFE2L2, SMAD3, PARP1, HIF1A, UBC, SUMO2, Bach1, HDAC3, HDAC2, HDAC1, CREBBP, RELA, KAT6A, TP53, BACH2, NFE2L3, NFE2, MARS, MAFK, NFE2L1, HOXD12,
    Protein Size: 156
    Molekulargewicht
    17 kDa
    Gen-ID
    7975
    NCBI Accession
    NM_002360, NP_002351
    UniProt
    O60675
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