MAFK Antikörper (N-Term)

Produktnummer ABIN2783019

Der Kaninchen Polyklonal anti-MAFK Antikörper wird verwendet zum Nachweis von MAFK in Proben von Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Zebrafisch (Danio rerio), Hund, Pferd, Kaninchen und Schaf. Er wurde validiert für WB.

Kurzübersicht für MAFK Antikörper (N-Term) (ABIN2783019)

Target: MAFK (Transcription Factor MafK (MAFK))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Zebrafisch (Danio rerio), Hund, Pferd, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAFK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MAFK Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: MAFK Antibody - N-terminal region

Sequenz: KEAGENAPVL SDDELVSMSV RELNQHLRGL TKEEVTRLKQ RRRTLKNRGY

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 79%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against MAFK. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAFK

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8114196

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu MAFK

Target: MAFK (Transcription Factor MafK (MAFK))

Andere Bezeichnung: MAFK

Hintergrund:

Background Information: The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2. NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, PBGD and FECH. NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG, or MafK) and p45. Both subunits are members of the activator protein-1 superfamily of bZIP proteins. Maf homodimers suppress transcription at NFE2 sites.The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD, MIM 176000) and ferrochelatase (FECH, MIM 177000). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM].

Gene Name: V-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)

Alternative Symbols: P18, NFE2U

Protein Name: Transcription factor MafK

Molekulargewicht: 17kDa

Gen-ID: 7975

NCBI Accession: NP_002351

UniProt: O60675