KIRREL Antikörper (Middle Region)

Produktnummer ABIN2782952

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch KIRREL in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen.Es wurde in 1 Publikation zitiert.

Kurzübersicht für KIRREL Antikörper (Middle Region) (ABIN2782952)

Target: KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIRREL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KIRREL Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: KIRREL1 Antibody - middle region

Sequenz: FLEVGTLERY TVERTNSGSG VLSTLTINNV MEADFQTHYN CTAWNSFGPG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KIRREL. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KIRREL

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47408-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-KIRREL Antikörper (ABIN2782952)

Ito, Sugihara, Asaka, Toyama, Yoshihara, Furuichi, Wada, Asano: "Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice." in: PLoS ONE, Vol. 7, Issue 1, pp. e29873, (2012) (PubMed).

Details zu KIRREL

Target: KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))

Andere Bezeichnung: KIRREL1

Hintergrund:

Background Information: NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2, MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008]

Gene Name: kirre like nephrin family adhesion molecule 1

Alternative Symbols: NEPH1, KIRREL, NPHS23

Protein Name: kin of IRRE-like protein 1

Molekulargewicht: 84 kDa

Gen-ID: 55243

NCBI Accession: NP_060710

UniProt: Q96J84

Pathways: Regulation of Actin Filament Polymerization