KIRREL Antikörper (Middle Region)

Produktnummer ABIN2782952

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch KIRREL in WB. Er zeigt eine Reaktivität gegenüber Maus, Human, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen und wurde in 1 Publikation erwähnt.

Kurzübersicht für KIRREL Antikörper (Middle Region) (ABIN2782952)

Target: KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))

Reaktivität: Maus, Human, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIRREL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KIRREL Antikörper

Bindungsspezifität: Middle Region

Sequenz: FLEVGTLERY TVERTNSGSG VLSTLTINNV MEADFQTHYN CTAWNSFGPG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KIRREL. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KIRREL

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 757 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-KIRREL Antikörper (ABIN2782952)

Ito, Sugihara, Asaka, Toyama, Yoshihara, Furuichi, Wada, Asano: "Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice." in: PLoS ONE, Vol. 7, Issue 1, pp. e29873, (2012) (PubMed).

Details zu KIRREL

Target: KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))

Andere Bezeichnung: KIRREL

Hintergrund: KIRREL (NEPH1) is a member of the nephrin-like protein family, which includes NEPH2 and NEPH3. The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2, MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-337 AY302131.1 1-337 338-3211 BC109193.1 1-2874 3212-3609 AK001707.1 1904-2301 3610-3628 BC082969.1 2273-2291
Alias Symbols: FLJ10845, MGC129542, MGC129543, NEPH1
Protein Interaction Partner: UBC, SAV1, LATS1, GRB2, KIRREL, NPHS2, NPHS1, TJP1,
Protein Size: 757

Molekulargewicht: 84 kDa

Gen-ID: 55243

NCBI Accession: NM_018240, NP_060710

UniProt: Q96J84

Pathways: Regulation of Actin Filament Polymerization