NAGPA Antikörper (N-Term)

Produktnummer ABIN2782884

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NAGPA in WB. Es zeigt Reaktivität gegenüber Proben von Human, Rind (Kuh), Hund, Meerschweinchen, Pferd, Maus, Ratte und Zebrafisch (Danio rerio).

Kurzübersicht für NAGPA Antikörper (N-Term) (ABIN2782884)

Target: NAGPA (N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA))

Reaktivität: Human, Rind (Kuh), Hund, Meerschweinchen, Pferd, Maus, Ratte, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAGPA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NAGPA Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: NAGPA Antibody - N-terminal region

Sequenz: GECLGNVVSD ERRVSSSGGL QNAQFGIRRD GTLVTGYLSE EEVLDTENPF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against NAGPA. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human NAGPA

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47241-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu NAGPA

Target: NAGPA (N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA))

Andere Bezeichnung: NAGPA

Hintergrund:

Background Information: Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network.

Gene Name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

Alternative Symbols: UCE, APAA

Protein Name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

Molekulargewicht: 53kDa

Gen-ID: 51172

NCBI Accession: NP_057340

UniProt: Q9UK23