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SIGLEC7 Antikörper (Middle Region)

SIGLEC7 Reaktivität: Human, Rind (Kuh), Hund, Pferd, Meerschweinchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2782809
  • Target Alle SIGLEC7 Antikörper anzeigen
    SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
    Bindungsspezifität
    • 10
    • 9
    • 8
    • 8
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 86
    • 12
    • 3
    • 3
    • 1
    • 1
    Human, Rind (Kuh), Hund, Pferd, Meerschweinchen
    Wirt
    • 62
    • 24
    Kaninchen
    Klonalität
    • 62
    • 23
    • 1
    Polyklonal
    Konjugat
    • 37
    • 12
    • 10
    • 9
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIGLEC7 Antikörper ist unkonjugiert
    Applikation
    • 63
    • 44
    • 40
    • 17
    • 10
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    WRSLTLYPSQ PSNPLVLELQ VHLGDEGEFT CRAQNSLGSQ HVSLNLSLQQ
    Homologie
    Cow: 85%, Dog: 100%, Guinea Pig: 86%, Horse: 92%, Human: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against SIGLEC7. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human SIGLEC7
    Top Product
    Discover our top product SIGLEC7 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 467 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Jaroenpool, Rogers, Pattanapanyasat, Villinger, Onlamoon, Crocker, Ansari: "Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates." in: Cellular immunology, Vol. 250, Issue 1-2, pp. 91-104, (2008) (PubMed).

  • Target
    SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
    Andere Bezeichnung
    SIGLEC7 (SIGLEC7 Produkte)
    Synonyme
    SIGLEC7 antikoerper, AIRM1 antikoerper, CD328 antikoerper, CDw328 antikoerper, D-siglec antikoerper, QA79 antikoerper, SIGLEC-7 antikoerper, SIGLEC19P antikoerper, SIGLECP2 antikoerper, p75 antikoerper, p75/AIRM1 antikoerper, sialic acid-binding Ig-like lectin 7 antikoerper, sialic acid binding Ig like lectin 7 antikoerper, LOC468976 antikoerper, SIGLEC7 antikoerper
    Hintergrund
    SIGLEC7 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. In the immune response, it may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC7 mediates inhibition of natural killer cells cytotoxicity. It may also play a role in hemopoiesis. SIGLEC7 inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
    Alias Symbols: AIRM1, CDw328, D-siglec, QA79, SIGLEC-7, p75, p75/AIRM1, CD328
    Protein Interaction Partner: SOCS3, TRAF4, PTPN11, GRB2,
    Protein Size: 467
    Molekulargewicht
    51 kDa
    Gen-ID
    27036
    NCBI Accession
    NM_014385, NP_055200
    UniProt
    Q9Y286
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