SIGLEC7 Antikörper (Middle Region)
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- Target Alle SIGLEC7 Antikörper anzeigen
- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Rind (Kuh), Hund, Pferd, Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SIGLEC7 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- WRSLTLYPSQ PSNPLVLELQ VHLGDEGEFT CRAQNSLGSQ HVSLNLSLQQ
- Homologie
- Cow: 85%, Dog: 100%, Guinea Pig: 86%, Horse: 92%, Human: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against SIGLEC7. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human SIGLEC7
- Top Product
- Discover our top product SIGLEC7 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 467 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates." in: Cellular immunology, Vol. 250, Issue 1-2, pp. 91-104, (2008) (PubMed).
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Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates." in: Cellular immunology, Vol. 250, Issue 1-2, pp. 91-104, (2008) (PubMed).
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- Target
- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
- Andere Bezeichnung
- SIGLEC7 (SIGLEC7 Produkte)
- Synonyme
- SIGLEC7 antikoerper, AIRM1 antikoerper, CD328 antikoerper, CDw328 antikoerper, D-siglec antikoerper, QA79 antikoerper, SIGLEC-7 antikoerper, SIGLEC19P antikoerper, SIGLECP2 antikoerper, p75 antikoerper, p75/AIRM1 antikoerper, sialic acid-binding Ig-like lectin 7 antikoerper, sialic acid binding Ig like lectin 7 antikoerper, LOC468976 antikoerper, SIGLEC7 antikoerper
- Hintergrund
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SIGLEC7 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. In the immune response, it may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC7 mediates inhibition of natural killer cells cytotoxicity. It may also play a role in hemopoiesis. SIGLEC7 inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Alias Symbols: AIRM1, CDw328, D-siglec, QA79, SIGLEC-7, p75, p75/AIRM1, CD328
Protein Interaction Partner: SOCS3, TRAF4, PTPN11, GRB2,
Protein Size: 467 - Molekulargewicht
- 51 kDa
- Gen-ID
- 27036
- NCBI Accession
- NM_014385, NP_055200
- UniProt
- Q9Y286
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