BACE2 Antikörper (Middle Region)

Produktnummer ABIN2782767

Der Kaninchen Polyklonal anti-BACE2 Antikörper wird verwendet zum Nachweis von BACE2 in Proben von Human, Ratte, Maus, Meerschweinchen, Rind (Kuh), Hund, Pferd, Kaninchen und Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für BACE2 Antikörper (Middle Region) (ABIN2782767)

Target: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Rind (Kuh), Hund, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BACE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BACE2 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: BACE2 Antibody - middle region

Sequenz: SLNLDCREYN ADKAIVDSGT TLLRLPQKVF DAVVEAVARA SLIPEFSDGF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 85%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against BACE2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BACE2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46852-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu BACE2

Target: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Andere Bezeichnung: BACE2

Hintergrund:

Background Information: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.

Gene Name: Beta-site APP-cleaving enzyme 2

Alternative Symbols: ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1

Protein Name: Beta-secretase 2

Molekulargewicht: 37kDa

Gen-ID: 25825

NCBI Accession: NP_620477

UniProt: Q9Y5Z0