Reticulon 4 Antikörper (Middle Region)

Produktnummer ABIN2782749

Der Kaninchen Polyklonal Anti-Reticulon 4-Antikörper wurde für WB validiert. Er ist geeignet, Reticulon 4 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Schaf, Pferd, Meerschweinchen, Schwein und Zebrafisch (Danio rerio) zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für Reticulon 4 Antikörper (Middle Region) (ABIN2782749)

Target: Reticulon 4 (RTN4)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Schaf, Pferd, Meerschweinchen, Schwein, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Reticulon 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Reticulon 4 Antikörper

Bindungsspezifität: Middle Region

Sequenz: FRIYKGVIQA IQKSDEGHPF RAYLESEVAI SEELVQKYSN SALGHVNCTI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against RTN4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RTN4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 392 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Reticulon 4 Antikörper (ABIN2782749)

Beetz, Koch, Khundadze, Zimmer, Nietzsche, Hertel, Huebner, Mumtaz, Schweizer, Dirren, Karle, Irintchev, Alvarez, Redies, Westermann, Kurth, Deufel, Kessels, Qualmann, Hübner: "A spastic paraplegia mouse model reveals REEP1-dependent ER shaping." in: The Journal of clinical investigation, Vol. 123, Issue 10, pp. 4273-82, (2013) (PubMed).

Details zu Reticulon 4

Target: Reticulon 4 (RTN4)

Andere Bezeichnung: RTN4

Hintergrund: RTN4 belongs to the family of reticulons. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. RTN4 is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates.This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.
Alias Symbols: ASY, NI220/250, NOGO, NOGO-A, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C
Protein Interaction Partner: HUWE1, SYT16, ZFYVE21, RTN4, SNX15, ARL6IP1, SNX1, UBC, RPA3, RPA2, RPA1, vpu, BAIAP2, LAMA4, ATF2, CLN8, TMEM65, S100A16, EPPK1, SNX12, ACAA2, SLC9A3R2, TJP1, HNRNPM, ILF3, IGFBP7, DDB1, SLC25A10, CIRBP, TERF1, POT1, RPS27, NR4A1, HLA-DPB1, RTN3, RTN4IP1
Protein Size: 392

Molekulargewicht: 42 kDa

Gen-ID: 57142

NCBI Accession: NM_207520, NP_997403

UniProt: Q9NQC3

Pathways: Neurotrophin Signalübertragung, Regulation of Cell Size, SARS-CoV-2 Protein Interaktom