LMAN1 Antikörper (N-Term)

Produktnummer ABIN2782680

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch LMAN1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Schwein, Kaninchen, Zebrafisch (Danio rerio) und Meerschweinchen.

Kurzübersicht für LMAN1 Antikörper (N-Term) (ABIN2782680)

Target: LMAN1 (Lectin, Mannose-Binding, 1 (LMAN1))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Schwein, Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LMAN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-LMAN1 Antikörper

Bindungsspezifität: N-Term

Sequenz: DPAVALPHRR FEYKYSFKGP HLVQSDGTVP FWAHAGNAIP SSDQIRVAPS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against LMAN1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LMAN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 510 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu LMAN1

Target: LMAN1 (Lectin, Mannose-Binding, 1 (LMAN1))

Andere Bezeichnung: LMAN1

Hintergrund: LMAN1 is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in its gene are associated with a coagulation defect. Using positional cloning, its gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58
Protein Interaction Partner: UBC, NEDD8, YIPF3, env, PIGS, TMED2, YBX1, HSP90AA1, HNRNPU, APP, UBXN6, RAB3GAP2, RAB3GAP1, COPE, TUBB4B, TUBB3, COPB2, VCP, DNAJC7, P4HB, HSPA8, HSPA1A, COPB1, COPA, BCAP29, BCAP31, HLA-A, CANX, ELAVL1, MCFD2, F8,
Protein Size: 510

Molekulargewicht: 54 kDa

Gen-ID: 3998

NCBI Accession: NM_005570, NP_005561

UniProt: P49257