PFAS Antikörper (N-Term)

Produktnummer ABIN2782529

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PFAS in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Rind (Kuh), Meerschweinchen, Pferd und Kaninchen. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für PFAS Antikörper (N-Term) (ABIN2782529)

Target: PFAS (Phosphoribosylformylglycinamidine Synthase (PFAS))

Reaktivität: Human, Maus, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PFAS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PFAS Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: PFAS Antibody - N-terminal region

Sequenz: ESIMSTQESS NPNNVLKFCD NSSAIQGKEV RFLRPEDPTR PSRFQQQQGL

Homologie: Cow: 83%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 92%, Rabbit: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against PFAS. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PFAS

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46181-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PFAS Antikörper (ABIN2782529)

French, Zhao, An, Niessen, Deng, Cravatt, Benkovic: "Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 7, pp. 2528-33, (2013) (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Details zu PFAS

Target: PFAS (Phosphoribosylformylglycinamidine Synthase (PFAS))

Andere Bezeichnung: PFAS

Hintergrund:

Background Information: Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. PFAS catalyzes the fourth step of IMP biosynthesis. Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis.

Gene Name: Phosphoribosylformylglycinamidine synthase

Alternative Symbols: PURL, FGAMS, GATD8, FGARAT, FGAR-AT

Protein Name: Phosphoribosylformylglycinamidine synthase

Molekulargewicht: 145kDa

Gen-ID: 5198

NCBI Accession: NP_036525

UniProt: O15067