PFAS Antikörper (N-Term)

Produktnummer ABIN2782529

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PFAS in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Rind (Kuh), Meerschweinchen, Pferd und Kaninchen und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für PFAS Antikörper (N-Term) (ABIN2782529)

Target: PFAS (Phosphoribosylformylglycinamidine Synthase (PFAS))

Reaktivität: Human, Maus, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PFAS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PFAS Antikörper

Bindungsspezifität: N-Term

Sequenz: ESIMSTQESS NPNNVLKFCD NSSAIQGKEV RFLRPEDPTR PSRFQQQQGL

Homologie: Cow: 83%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 92%, Rabbit: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against PFAS. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PFAS

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1338 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PFAS Antikörper (ABIN2782529)

French, Zhao, An, Niessen, Deng, Cravatt, Benkovic: "Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 7, pp. 2528-33, (2013) (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Details zu PFAS

Target: PFAS (Phosphoribosylformylglycinamidine Synthase (PFAS))

Andere Bezeichnung: PFAS

Hintergrund: Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. PFAS catalyzes the fourth step of IMP biosynthesis. Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis.
Alias Symbols: FGAMS, FGARAT, KIAA0361, PURL
Protein Interaction Partner: UBC, SUMO2, TNRC6B, GINS3, ISOC1, BZW2, DCPS, MAT2B, ABHD14A, ERP44, PDCD10, FERMT2, NPEPPS, CNBP, YWHAZ, VCL, RAP1GDS1, PAK2, MSN, LDHB, HSPA9, EIF5, EEF2, ECHS1, DFFA, CKB, CAPN1, SGTA, XIAP, UBR1, USP28, PPP6R3, ZNF593, SEPHS1, CHERP, PRDX6, USP14, UBD
Protein Size: 1338

Molekulargewicht: 145 kDa

Gen-ID: 5198

NCBI Accession: NM_012393, NP_036525

UniProt: O15067