CSTB Antikörper (N-Term)

Produktnummer ABIN2782350

Der Kaninchen Polyklonal anti-CSTB Antikörper (ABIN2782350) detektiert spezifisch CSTB in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Rind (Kuh), Pferd, Schwein, Schaf, Kaninchen und Meerschweinchen.

Kurzübersicht für CSTB Antikörper (N-Term) (ABIN2782350)

Target: CSTB (Cystatin B (Stefin B) (CSTB))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Pferd, Schwein, Schaf, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CSTB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-CSTB Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: CSTB Antibody - N-terminal region

Sequenz: MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG

Homologie: Cow: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 79%, Rat: 86%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CSTB. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CSTB

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45749-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu CSTB

Target: CSTB (Cystatin B (Stefin B) (CSTB))

Andere Bezeichnung: CSTB

Hintergrund:

Background Information: CSTB is a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in CSTB gene are responsible for the primary defects in patients with progressive myoclonic epilepsy a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy.The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).

Gene Name: Cystatin B (stefin B)

Alternative Symbols: PME, ULD, CST6, EPM1, STFB, CPI-B, EPM1A

Protein Name: Cystatin-B

Molekulargewicht: 11kDa

Gen-ID: 1476

NCBI Accession: NP_000091

UniProt: P04080

Pathways: Response to Water Deprivation