Estrogen Receptor alpha Antikörper (Middle Region)

Produktnummer ABIN2782261

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Estrogen Receptor alpha in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Rind (Kuh), Schwein, Hund und Schaf.

Kurzübersicht für Estrogen Receptor alpha Antikörper (Middle Region) (ABIN2782261)

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Reaktivität: Human, Ratte, Rind (Kuh), Schwein, Hund, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Estrogen Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Estrogen Receptor alpha Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: ESR1 Antibody - middle region

Sequenz: LLEMLDAHRL HAPTSRGGAS VEETDQSHLA TAGSTSSHSL QKYYITGEAE

Homologie: Cow: 83%, Dog: 79%, Human: 100%, Pig: 79%, Rat: 86%, Sheep: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against ESR1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ESR1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45592-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Andere Bezeichnung: ESR1

Hintergrund:

Background Information: Hairy/enhancer of split-related proteins, such as HEY1, are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. HEY genes are direct transcriptional targets of the Notch signaling pathways in Drosophila and vertebrates. This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Gene Name: Estrogen receptor 1

Alternative Symbols: ER, ESR, Era, ESRA, ESTRR, NR3A1

Protein Name: Estrogen receptor

Molekulargewicht: 66kDa

Gen-ID: 2099

NCBI Accession: NP_000116

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly