TGFB2 Antikörper (Middle Region)

Produktnummer ABIN2782223

Produktdetails anti-TGFB2 Antikörper

Target: TGFB2 (Transforming Growth Factor, beta 2 (TGFB2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Pferd, Kaninchen, Schaf, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TGFB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NLVKAEFRVF RLQNPKARVP EQRIELYQIL KSKDLTSPTQ RYIDSKVVKT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against TGFB2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TGFB2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 414 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TGFB2

Target: TGFB2 (Transforming Growth Factor, beta 2 (TGFB2))

Andere Bezeichnung: TGFB2 (TGFB2 Produkte)

Synonyme: LDS4 antikoerper, TGF-beta2 antikoerper, tgf-beta2 antikoerper, tgfb2-A antikoerper, BB105277 antikoerper, Tgf-beta2 antikoerper, Tgfb-2 antikoerper, TGF-beta 2 antikoerper, Tgfbr2T antikoerper, TGFB2 antikoerper, TGFbeta2 antikoerper, MGF antikoerper, TGF-B2 antikoerper, transforming growth factor beta 2 antikoerper, transforming growth factor beta 2 L homeolog antikoerper, transforming growth factor, beta 2 antikoerper, transforming growth factor, beta receptor 2 antikoerper, TGFB2 antikoerper, tgfb2.L antikoerper, Tgfb2 antikoerper, Tgfbr2 antikoerper, tgfb2 antikoerper

Hintergrund: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1,7)(q41,p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: MGC116892, TGF-beta2
Protein Interaction Partner: CEBPA, UBC, VASN, PZP, LTBP3, TGFBR3, FMOD, VTN, TGFB3, TGFB2, TGFBR2, TGFBR1, TGFB1, ENG, CTGF, BMP2, APP, TGFBRAP1, DAXX, DCN,
Protein Size: 414

Molekulargewicht: 46 kDa

Gen-ID: 7042

NCBI Accession: NM_003238, NP_003229

UniProt: P61812

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus