TGFB2 Antikörper (Middle Region)

Produktnummer ABIN2782223

Der Kaninchen Polyklonal anti-TGFB2 Antikörper wird verwendet zum Nachweis von TGFB2 in Proben von Human, Ratte, Maus, Rind (Kuh), Hund, Schwein, Pferd, Kaninchen, Schaf, Meerschweinchen und Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für TGFB2 Antikörper (Middle Region) (ABIN2782223)

Target: TGFB2 (Transforming Growth Factor, beta 2 (TGFB2))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Schwein, Pferd, Kaninchen, Schaf, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TGFB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TGFB2 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: TGFB2 Antibody - middle region

Sequenz: NLVKAEFRVF RLQNPKARVP EQRIELYQIL KSKDLTSPTQ RYIDSKVVKT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against TGFB2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TGFB2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45446-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu TGFB2

Target: TGFB2 (Transforming Growth Factor, beta 2 (TGFB2))

Andere Bezeichnung: TGFB2

Hintergrund:

Background Information: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1,7)(q41,p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: Transforming growth factor, beta 2

Alternative Symbols: LDS4, G-TSF, TGF-beta2

Protein Name: Transforming growth factor beta-2

Molekulargewicht: 46kDa

Gen-ID: 7042

NCBI Accession: NP_003229

UniProt: P61812

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus