PIGA Antikörper (Middle Region)

Produktnummer ABIN2782189

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-PIGA Antikörper wird verwendet zum Nachweis von PIGA in Proben von Human, Maus, Ratte, Rind (Kuh), Schwein, Kaninchen und Hund. Er wurde validiert für WB.

Kurzübersicht für PIGA Antikörper (Middle Region) (ABIN2782189)

Target: PIGA (Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIGA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PIGA Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: PIGA Antibody - middle region

Sequenz: SVKSLCEGLE KAIFQLKSGT LPAPENIHNI VKTFYTWRNV AERTEKVYDR

Homologie: Cow: 86%, Dog: 93%, Human: 100%, Mouse: 93%, Pig: 79%, Rabbit: 79%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against PIGA. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PIGA

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45344-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PIGA Antikörper (ABIN2782189)

Traulsen, Pacheco, Dingli: "On the origin of multiple mutant clones in paroxysmal nocturnal hemoglobinuria." in: Stem cells (Dayton, Ohio), Vol. 25, Issue 12, pp. 3081-4, (2007) (PubMed).

Details zu PIGA

Target: PIGA (Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA))

Andere Bezeichnung: PIGA

Hintergrund:

Targeted Subunit: A

Background Information: PIGA is a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene.This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized.

Gene Name: Phosphatidylinositol glycan anchor biosynthesis, class A

Alternative Symbols: GPI3, PNH1, PIG-A, MCAHS2

Protein Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Ensembl ENSP00000416102

Molekulargewicht: 19kDa

Gen-ID: 5277

NCBI Accession: NP_065206

UniProt: B3KUV7

Pathways: Inositol Metabolic Process