POMT1 Antikörper (Middle Region)

Produktnummer ABIN2782091

Der Kaninchen Polyklonal anti-POMT1 Antikörper (ABIN2782091) detektiert spezifisch POMT1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Pferd und Kaninchen.

Kurzübersicht für POMT1 Antikörper (Middle Region) (ABIN2782091)

Target: POMT1 (Protein-O-Mannosyltransferase 1 (POMT1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POMT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-POMT1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: POMT1 Antibody - middle region

Sequenz: LTFQILLLPV VLQHISDHLC RSQLQRSIFS ALVVAWYSSA CHVSNTLRPL

Homologie: Cow: 86%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 86%, Rabbit: 77%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against POMT1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human POMT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44994-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu POMT1

Target: POMT1 (Protein-O-Mannosyltransferase 1 (POMT1))

Andere Bezeichnung: POMT1

Hintergrund:

Background Information: POMT1 is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K).O-mannosylation is an important protein modification in eukaryotes that is initiated by an evolutionarily conserved family of protein O-mannosyltransferases. POMT1 shares sequence similarity with protein O-mannosyltransferases of S. cerevisiae. In yeast, these enzymes are located in the endoplasmic reticulum (ER) and are required for cell integrity and cell wall rigidity. POMT1 also shows similarity to the Drosophila 'rotated abdomen' (rt) gene, which when mutated causes defects in myogenesis and muscle structure.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-42 DB154785.1 1-42 43-2420 AK074874.1 1-2378 2421-2617 BF984005.1 438-634 2618-3080 AL358781.19 127610-128072

Gene Name: Protein-O-mannosyltransferase 1

Alternative Symbols: RT, LGMD2K, MDDGA1, MDDGB1, MDDGC1, LGMDR11

Protein Name: Protein O-mannosyl-transferase 1

Molekulargewicht: 82kDa

Gen-ID: 10585

NCBI Accession: NP_001070833

UniProt: B3KQG0