Ectodysplasin A Antikörper (Middle Region)

Produktnummer ABIN2781905

Produktdetails anti-Ectodysplasin A Antikörper

Target: Ectodysplasin A (EDA)

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege, Meerschweinchen, Pferd, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ectodysplasin A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: HLQGQGSAIQ VKNDLSGGVL NDWSRITMNP KVFKLHPRSG ELEVLVDGTY

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against EDA. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human EDA

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 389 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Ectodysplasin A Antikörper (ABIN2781905)

Zhao, Watt, Battle, Li, Bondow, Duncan: "Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice." in: Developmental biology, Vol. 317, Issue 2, pp. 614-9, (2008) (PubMed).

Details zu Ectodysplasin A

Target: Ectodysplasin A (EDA)

Andere Bezeichnung: EDA (EDA Produkte)

Synonyme: ECTD1 antikoerper, ED1 antikoerper, ED1-A1 antikoerper, ED1-A2 antikoerper, EDA-A1 antikoerper, EDA-A2 antikoerper, EDA1 antikoerper, EDA2 antikoerper, HED antikoerper, HED1 antikoerper, ODT1 antikoerper, STHAGX1 antikoerper, XHED antikoerper, XLHED antikoerper, si:ch73-223d24.5 antikoerper, Ed1 antikoerper, Eda-A1 antikoerper, Eda-A2 antikoerper, Ta antikoerper, tabby antikoerper, RGD1563178 antikoerper, ectodysplasin A antikoerper, ectodysplasin-A antikoerper, EDA antikoerper, eda antikoerper, Eda antikoerper

Hintergrund: EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. It belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
Alias Symbols: ED1, ED1-A1, ED1-A2, EDA1, EDA2, HED, XHED, XLHED, ODT1, STHAGX1
Protein Interaction Partner: OSTCP1, OSTC, NIPAL3, GIMAP5, SEC22A, LEPROTL1, DOLK, PLN, MAL, EMP3, CYB561, ATP6V0C, EDAR, EDA, EDA2R, FURIN,
Protein Size: 389

Molekulargewicht: 41 kDa

Gen-ID: 1896

NCBI Accession: NM_001005609, NP_001005609

UniProt: B7ZLU4

Pathways: Tube Formation