MTTP Antikörper (N-Term)

Produktnummer ABIN2781495

Der Kaninchen Polyklonal Anti-MTTP-Antikörper wurde für WB validiert. Er ist geeignet, MTTP in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für MTTP Antikörper (N-Term) (ABIN2781495)

Target: MTTP (Microsomal Triglyceride Transfer Protein (MTTP))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MTTP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MTTP Antikörper

Bindungsspezifität: N-Term

Sequenz: MILLAVLFLC FISSYSASVK GHTTGLSLNN DRLYKLTYST EVLLDRGKGK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MTTP. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MTTP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 894 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MTTP Antikörper (ABIN2781495)

Lee, Bao, Ishikawa, Wang, Lim: "Cardiomyocyte Regulation of Systemic Lipid Metabolism by the Apolipoprotein B-Containing Lipoproteins in Drosophila." in: PLoS genetics, Vol. 13, Issue 1, pp. e1006555, (2017) (PubMed).

Ward, Dail, Chambers: "In Vitro effect of DDE exposure on the regulation of lipid metabolism and secretion in McA-RH7777 hepatocytes: A potential role in dyslipidemia which may increase the risk of type 2 diabetes mellitus." in: Toxicology in vitro : an international journal published in association with BIBRA, Vol. 37, pp. 9-14, (2016) (PubMed).

Lundahl, Skoglund-Andersson, Caslake, Bedford, Stewart, Hamsten, Packard, Karpe: "Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles." in: American journal of physiology. Endocrinology and metabolism, Vol. 290, Issue 4, pp. E739-45, (2006) (PubMed).

Details zu MTTP

Target: MTTP (Microsomal Triglyceride Transfer Protein (MTTP))

Andere Bezeichnung: MTTP

Hintergrund: MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
Alias Symbols: ABL, MGC149819, MGC149820, MTP
Protein Interaction Partner: HSP90B1, APOB,
Protein Size: 894

Molekulargewicht: 97 kDa

Gen-ID: 4547

NCBI Accession: NM_000253, NP_000244

UniProt: P55157

Pathways: Transition Metal Ion Homeostasis