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NUP98 Antikörper (N-Term)

NUP98 Reaktivität: Human, Maus, Ratte, Hund, Pferd, Kaninchen, Rind (Kuh), Meerschweinchen, Saccharomyces cerevisiae, Zebrafisch (Danio rerio) WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2781008
  • Target Alle NUP98 Antikörper anzeigen
    NUP98 (Nucleoporin 98kDa (NUP98))
    Bindungsspezifität
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 47
    • 15
    • 11
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Pferd, Kaninchen, Rind (Kuh), Meerschweinchen, Saccharomyces cerevisiae, Zebrafisch (Danio rerio)
    Wirt
    • 35
    • 11
    • 2
    Kaninchen
    Klonalität
    • 33
    • 15
    Polyklonal
    Konjugat
    • 38
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NUP98 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 16
    • 12
    • 11
    • 7
    • 4
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    Sequenz
    AFGTSAFGSS NNTGGLFGNS QTKPGGLFGT SSFSQPATST STGFGFGTST
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 91%, Zebrafish: 85%
    Produktmerkmale
    This is a rabbit polyclonal antibody against NUP98. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human NUP98
    Top Product
    Discover our top product NUP98 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 1800 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    NUP98 (Nucleoporin 98kDa (NUP98))
    Andere Bezeichnung
    NUP98 (NUP98 Produkte)
    Synonyme
    CG10198 antikoerper, CG10201 antikoerper, Dmel\\CG10198 antikoerper, Nup 96 antikoerper, Nup 98 antikoerper, Nup-98 antikoerper, Nup96 antikoerper, Nup98 antikoerper, Nup98-Nup96 antikoerper, Nup98/96 antikoerper, l(3)95BCd antikoerper, nup145 antikoerper, nup98-96 antikoerper, GB12688 antikoerper, NUP98 antikoerper, 4732457F17 antikoerper, AI849286 antikoerper, im:7151238 antikoerper, zgc:113968 antikoerper, zgc:63593 antikoerper, ADIR2 antikoerper, NUP196 antikoerper, NUP96 antikoerper, Nucleoporin 98-96kD antikoerper, nuclear pore complex protein Nup98-Nup96 antikoerper, nucleoporin 98 antikoerper, nucleoporin 98kDa antikoerper, nucleoporin 98 L homeolog antikoerper, Nup98-96 antikoerper, LOC408335 antikoerper, NUP98 antikoerper, LOC587580 antikoerper, Nup98 antikoerper, nup98 antikoerper, nup98.L antikoerper
    Hintergrund
    The nuclear pore complex (NPC) is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants, however, not all variants have been fully described.
    Alias Symbols: ADIR2, NUP196, NUP96
    Protein Interaction Partner: UBC, SUMO2, SUMO3, CDC37, EED, CDC73, PAF1, ARFGEF2, FBXO6, NXF1, HDAC11, HDAC8, LMNA, HNRNPUL1, CSNK2A1, ECT2, NUP107, RAE1, SUMO1, NUMA1, rev, SIRT7, RAPGEF3, CTNNB1, NUP88, NUP159, NUP82, Nup98, Nup214, Nup188, tat, HDAC1, CREBBP, PTTG1, APC, NPM1, USP
    Protein Size: 1800
    Molekulargewicht
    196 kDa
    Gen-ID
    4928
    NCBI Accession
    NM_016320, NP_057404
    Pathways
    Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interaktom
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