SUPT16H Antikörper (Middle Region)

Produktnummer ABIN2780836

Dieses Anti-SUPT16H-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SUPT16H in WB. Geeignet für Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Pferd, Kaninchen, Zebrafisch (Danio rerio) und Ziege.

Kurzübersicht für SUPT16H Antikörper (Middle Region) (ABIN2780836)

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Pferd, Kaninchen, Zebrafisch (Danio rerio), Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUPT16H Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SUPT16H Antikörper

Bindungsspezifität: Middle Region

Sequenz: EESDYSKESL GSEEESGKDW DELEEEARKA DRESRYEEEE EQSRSMSRKR

Homologie: Cow: 100%, Dog: 100%, Goat: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SUPT16H. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SUPT16H

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1047 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SUPT16H

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Andere Bezeichnung: SUPT16H

Hintergrund: Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is SUPT16H. Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is the protein encoded by this gene. Sequence Note: The sequence AF152961.1 is a chimeric mRNA clone. Only the SUPT16H region was propagated into this RefSeq record. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CDC68, FACT, FACTP140, FLJ10857, FLJ14010, FLJ34357, SPT16/CDC68
Protein Interaction Partner: HIST1H2AB, UBC, SUMO2, ATRX, SUMO1, NEDD8, RNF20, PAF1, EED, RNF2, BMI1, rev, FTH1, QRICH1, SRPK2, ICAM1, CD81, IGSF8, PNKP, VCP, FMNL1, SSRP1, ESR1, CENPA, LEO1, RBM25, PRPF6, NCSTN, RTF1, ACIN1, PSIP1, USP39, PRPF8, SF3A1, SAP18, CTR9, DDX21, PRPF3, PRP
Protein Size: 1047

Molekulargewicht: 120 kDa

Gen-ID: 11198

NCBI Accession: NM_007192, NP_009123

UniProt: Q9Y5B9

Pathways: Chromatin Binding