CTCF Antikörper (CCCTC-Binding Factor (Zinc Finger Protein)) (N-Term)

Details for Product anti-CTCF Antibody No. ABIN2780790, Anbieter: Anmelden zum Anzeigen
Antigen
  • im:7152666
  • CTCF
  • xctcf
  • AW108038
  • CCCTC-binding factor
  • CCCTC-binding factor (zinc finger protein)
  • CTCF
  • ctcf
  • Ctcf
Epitop
N-Term
14
7
6
5
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus)
88
44
29
12
10
8
6
6
4
4
3
2
2
1
1
1
Wirt
Kaninchen
58
28
6
1
1
Klonalität
Polyklonal
Applikation
Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
81
30
25
17
14
11
9
6
3
2
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human CTCF
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN975410.
Sequenz MEGDAVEAIV EESETFIKGK ERKTYQRRRE GGQEEDACHL PQNQTDGGEV
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against CTCF. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung CTCF (CTCF Antibody Abstract)
Hintergrund CTCF is a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in CTCF have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.
Protein Interaction Partner: ZMYM4, UBC, EED, BMI1, KANSL1, CDK19, ZMYM2, CAND1, ZBTB33, TFAP4, SUMO1, SUMO2, SUMO3, SIRT7, TAF3, SMC3, POLR2A, SUZ12, Ctcf, HIST2H2AC, TOP2A, TAF1, NPM1, LMNA, KPNA4, KPNA2, H2AFZ, PARP1, TRB, RXRA, SMAD3, SIN3A, SMC1A, RAD21, YY1, THRB, SMAD4, HMGB1,
Protein Size: 727
Molekulargewicht 83 kDa
Gen-ID 10664
NCBI Accession NM_006565, NP_006556
UniProt P49711
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 727 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Chromatin Immunoprecipitation (ChIP) image for anti-CCCTC-Binding Factor (Zinc Finger Protein) (CTCF) (N-Term) antibody (ABIN2780790) Chromatin Immunoprecipitation (ChIP) Using CTCF Antibody - N-terminal region (ARP3882...
Allgemeine Veröffentlichungen Defossez, Kelly, Filion, Pérez-Torrado, Magdinier, Menoni, Nordgaard, Daniel, Gilson: "The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso." in: The Journal of biological chemistry, Vol. 280, Issue 52, pp. 43017-23, 2005 (PubMed).

Haben Sie etwas anderes gesucht?