HIC1 Antikörper (Middle Region)

Produktnummer ABIN2780783

Der Kaninchen Polyklonal Anti-HIC1-Antikörper wurde für WB validiert. Er ist geeignet, HIC1 in Proben von Human, Maus, Ratte, Meerschweinchen, Hund, Rind (Kuh) und Pferd zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für HIC1 Antikörper (Middle Region) (ABIN2780783)

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Hund, Rind (Kuh), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HIC1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: GETPIAVMGE FANLATSLNP LDPDKDEEEE EEEESEDELP QDISLAAGGE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against HIC1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HIC1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 714 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HIC1 Antikörper (ABIN2780783)

Stöcklein, Smardova, Macak, Katzenberger, Höller, Wessendorf, Hutter, Dreyling, Haralambieva, Mäder, Müller-Hermelink, Rosenwald, Ott, Kalla: "Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma." in: Oncogene, Vol. 27, Issue 18, pp. 2613-25, (2008) (PubMed).

Details zu HIC1

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Andere Bezeichnung: HIC1

Hintergrund: HIC1 is a transcriptional repressor. HIC1 may act as a tumor suppressor. HIC1 may be involved in development of head, face, limbs and ventral body wall. Defects in HIC1 may be a cause of the facial dysmorphism and additional birth defects (except for lissencephaly) seen in the contiguous gene disorder Miller-Dieker syndrome (MDS), like defective development of the nose, jaws, extremities, gastrointestinal tract, and kidney.
Alias Symbols: ZBTB29, hic-1, ZNF901
Protein Interaction Partner: PIAS4, PIAS3, PIAS2, SP1, STAT3, SIRT1, MTA1, UBE2I, SUMO2, HIC2, TCF4, CTBP2, CTBP1, EED, PHF1, EZH2, PHF19, SUZ12, UBC, MBD3, RBBP4, CHD3, SENP3, HDAC4, PIAS1, ARID1A, HIC1, HDAC1,
Protein Size: 714

Molekulargewicht: 74 kDa

Gen-ID: 3090

NCBI Accession: NM_006497, NP_006488

UniProt: Q14526

Pathways: Positive Regulation of Response to DNA Damage Stimulus