TADA3L Antikörper (C-Term)

Produktnummer ABIN2780769

Produktdetails anti-TADA3L Antikörper

Target: TADA3L (TADA3) (Transcriptional Adaptor 3 (TADA3))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TADA3L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RVRMADNEVM DAFRKIMAAR QKKRTPTKKE KDQAWKTLKE RESILKLLDG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against TADA3L. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TADA3L

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 432 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TADA3L

Target: TADA3L (TADA3) (Transcriptional Adaptor 3 (TADA3))

Andere Bezeichnung: TADA3L (TADA3 Produkte)

Hintergrund: Adaptor proteins are usually required for transcriptional activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter.TADA3L is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis.Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.
Alias Symbols: ADA3, NGG1, hADA3, TADA3L
Protein Interaction Partner: HEXIM2, CCDC101, CCNC, TP53, USP22, KDM1A, TADA2A, KAT2B, TAF5L, NUP205, SUPT3H, YEATS2, MBIP, WDR5, MAP3K7, DR1, PIAS4, MAGEH1, ING5, XRCC6, SUMO2, SREBF1, TXNRD2, NR1I2, RARA, ESR1, AR, KAT2A, EP300, CTNNB1, ANKRD12, ATXN7, TAF10, FAM107B, ADPGK, HSPA8,
Protein Size: 432

Molekulargewicht: 49 kDa

Gen-ID: 10474

NCBI Accession: NM_006354, NP_006345

UniProt: O75528

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway