PPARD Antikörper (N-Term)

Produktnummer ABIN2780757

Produktdetails anti-PPARD Antikörper

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPARD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: MEQPQEEAPE VREEEEKEEV AEAEGAPELN GGPQHALPSS SYTDLSRSSS

Homologie: Cow: 80%, Dog: 79%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 79%, Rat: 93%, Yeast: 90%

Produktmerkmale: This is a rabbit polyclonal antibody against PPARD. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the n terminal region of human PPARD

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 441 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PPARD

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Andere Bezeichnung: PPARD (PPARD Produkte)

Synonyme: FAAR antikoerper, NR1C2 antikoerper, NUC1 antikoerper, NUCI antikoerper, NUCII antikoerper, PPARB antikoerper, NUC-1 antikoerper, Nr1c2 antikoerper, PPAR-beta antikoerper, PPAR-delta antikoerper, PPAR[b] antikoerper, PPARdelta antikoerper, Pparb antikoerper, Pparb/d antikoerper, PPARBETA antikoerper, ppard antikoerper, pparb antikoerper, PPARD antikoerper, PPAR-D/B antikoerper, peroxisome proliferator activated receptor delta antikoerper, peroxisome proliferator activator receptor delta antikoerper, peroxisome proliferator activated receptor delta S homeolog antikoerper, peroxisome proliferator-activated receptor delta antikoerper, PPARD antikoerper, Ppard antikoerper, ppard.S antikoerper, ppard antikoerper

Hintergrund: PPARD is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR delta and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
Alias Symbols: FAAR, MGC3931, NR1C2, NUC1, NUCI, NUCII, PPAR-beta, PPARB
Protein Interaction Partner: KRTAP10-3, KRTAP10-7, PLA2G4A, CTNNB1, KDM1A, PRMT3, SMAD9, HSP90AA1, TNP1, PSMG1, Nedd4, RANBP9, PRDX6, EIF3I, NCOA1, NR0B2, SHMT2, RXRG, RXRB, RXRA, PROX1, ITGB5, GLUL, RELA, HDAC1, EP300, NCOA2, SRC, SPEN, HDAC7, HDAC3, PEBP1, HDAC2, GADD45G, GADD45B,
Protein Size: 441

Molekulargewicht: 49 kDa

Gen-ID: 5467

NCBI Accession: NM_001039694, NP_001034783

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation