RBM5 Antikörper (N-Term)

Produktnummer ABIN2780715

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RBM5 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen und Saccharomyces cerevisiae.

Kurzübersicht für RBM5 Antikörper (N-Term) (ABIN2780715)

Target: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RBM5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RBM5 Antikörper

Bindungsspezifität: N-Term

Sequenz: GSDKRVSRTE RSGRYGSIID RDDRDERESR SRRRDSDYKR SSDDRRGDRY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 80%

Produktmerkmale: This is a rabbit polyclonal antibody against RBM5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RBM5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 815 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RBM5

Target: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Andere Bezeichnung: RBM5

Hintergrund: RBM5 is a component of the spliceosome A complex.It regulates alternative splicing of a number of mRNAs. RBM5 may modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. RBM5 may both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, RBM5 promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
Alias Symbols: FLJ39876, G15, H37, LUCA15, RMB5
Protein Interaction Partner: UBC, RNF2, SUZ12, WDR77, WBP11, LSM8, PRPF19, U2SURP, SNRNP200, U2AF2, PRPF8, ILF3, DHX15, LIG4, COPS5, SF3A2, SUMO2, GAPDH, BCL2L1, LRIF1,
Protein Size: 815

Molekulargewicht: 92 kDa

Gen-ID: 10181

NCBI Accession: NM_005778, NP_005769

UniProt: P52756

Pathways: Ribonucleoprotein Complex Subunit Organization