ONECUT1 Antikörper (Middle Region)

Produktnummer ABIN2780599

Zitiert in 2+ Publikationen. Der Kaninchen Polyklonal anti-ONECUT1 Antikörper (ABIN2780599) detektiert spezifisch ONECUT1 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Schwein, Pferd und Zebrafisch (Danio rerio).

Kurzübersicht für ONECUT1 Antikörper (Middle Region) (ABIN2780599)

Target: ONECUT1 (One Cut Homeobox 1 (ONECUT1))

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Schwein, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ONECUT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-ONECUT1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: ONECUT1 Antibody - middle region

Sequenz: ITISQQLGLE LSTVSNFFMN ARRRSLDKWQ DEGSSNSGNS SSSSSTCTKA

Homologie: Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against ONECUT1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ONECUT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38481-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ONECUT1 Antikörper (ABIN2780599)

Yuan, Wang, Hu, Tang, Shi, Guo, Song: "Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition." in: The Journal of biological chemistry, Vol. 288, Issue 43, pp. 31206-16, (2013) (PubMed).

Huang, Mei, Yu, Zhang, Han, Jiang, Zhou: "Distribution of the interstitial Cajal-like cells in the gallbladder and extrahepatic biliary duct of the guinea-pig." in: Acta histochemica, Vol. 111, Issue 2, pp. 157-65, (2009) (PubMed).

Details zu ONECUT1

Target: ONECUT1 (One Cut Homeobox 1 (ONECUT1))

Andere Bezeichnung: ONECUT1

Hintergrund:

Background Information: ONECUT1 belongs to the CUT homeobox family. It contains 1 CUT DNA-binding domain and 1 homeobox DNA-binding domain. It is a transcriptional activator. ONECUT1 binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. It is important for liver genes transcription.

Gene Name: One cut homeobox 1

Alternative Symbols: HNF6, HNF-6, HNF6A

Protein Name: Hepatocyte nuclear factor 6

Molekulargewicht: 51kDa

Gen-ID: 3175

NCBI Accession: NP_004489

UniProt: Q9UBC0