ONECUT1 Antikörper (Middle Region)

Produktnummer ABIN2780599

Dieser Anti-ONECUT1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von ONECUT1 in WB und IHC. Geeignet für Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Schwein, Pferd und Zebrafisch (Danio rerio). Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für ONECUT1 Antikörper (Middle Region) (ABIN2780599)

Target: ONECUT1 (One Cut Homeobox 1 (ONECUT1))

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Schwein, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ONECUT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-ONECUT1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: ITISQQLGLE LSTVSNFFMN ARRRSLDKWQ DEGSSNSGNS SSSSSTCTKA

Homologie: Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against ONECUT1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ONECUT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 465 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ONECUT1 Antikörper (ABIN2780599)

Yuan, Wang, Hu, Tang, Shi, Guo, Song: "Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition." in: The Journal of biological chemistry, Vol. 288, Issue 43, pp. 31206-16, (2013) (PubMed).

Huang, Mei, Yu, Zhang, Han, Jiang, Zhou: "Distribution of the interstitial Cajal-like cells in the gallbladder and extrahepatic biliary duct of the guinea-pig." in: Acta histochemica, Vol. 111, Issue 2, pp. 157-65, (2009) (PubMed).

Details zu ONECUT1

Target: ONECUT1 (One Cut Homeobox 1 (ONECUT1))

Andere Bezeichnung: ONECUT1

Hintergrund: ONECUT1 belongs to the CUT homeobox family. It contains 1 CUT DNA-binding domain and 1 homeobox DNA-binding domain. It is a transcriptional activator. ONECUT1 binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. It is important for liver genes transcription.
Alias Symbols: HNF-6, HNF6, HNF6A
Protein Interaction Partner: NR0B2, KAT2B, FOXA2, CREBBP, NR3C1, FOXA1,
Protein Size: 465

Molekulargewicht: 51 kDa

Gen-ID: 3175

NCBI Accession: NM_004498, NP_004489

UniProt: Q9UBC0