THRB Antikörper (N-Term)

Produktnummer ABIN2780344

Dieses Anti-THRB-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von THRB in WB und ChIP. Geeignet für Human, Maus, Ratte, Pferd, Hund, Kaninchen und Schaf.

Kurzübersicht für THRB Antikörper (N-Term) (ABIN2780344)

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Reaktivität: Human, Maus, Ratte, Pferd, Hund, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THRB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Produktdetails anti-THRB Antikörper

Bindungsspezifität: N-Term

Sequenz: MTPNSMTENG LTAWDKPKHC PDREHDWKLV GMSEACLHRK SHSERRSTLK

Homologie: Dog: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Sheep: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against THRB. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human THRB

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 461 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu THRB

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Andere Bezeichnung: THRB

Hintergrund: THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Alias Symbols: ERBA-BETA, ERBA2, GRTH, MGC126109, MGC126110, NR1A2, THR1, THRB1, THRB2, PRTH, C-ERBA-2, C-ERBA-BETA
Protein Interaction Partner: NSD1, NCOA1, RANBP9, NCOR1, RXRA, THRB, MMS19, ADAT3, NCOA2, C1D, NCOA3, ATF2, ANP32A, SUMO1, SUMO2, ROBO4, MED21, HMGN3, EIF3I, NRIP1, RXRG, RXRB, CAMK2B, TBL1XR1, NCOR2, HDAC3, SMC1A, XRCC5, TBL1X, PRKDC, LIG3, HSPA4, GPS2, XRCC6, PARP1, LRIF1, SRC, PSM
Protein Size: 461

Molekulargewicht: 53 kDa

Gen-ID: 7068

NCBI Accession: NM_000461, NP_000452

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound