RFX5 Antikörper (N-Term)
-
- Target Alle RFX5 Antikörper anzeigen
- RFX5 (Regulatory Factor X 5 (RFX5))
-
Bindungsspezifität
- N-Term
-
Reaktivität
- Human, Ratte, Kaninchen, Hund, Meerschweinchen, Pferd, Schwein
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser RFX5 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Sequenz
- MAEDEPDAKS PKTGGRAPPG GAEAGEPTTL LQRLRGTISK AVQNKVEGIL
- Homologie
- Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Pig: 86%, Rabbit: 86%, Rat: 79%
- Produktmerkmale
- This is a rabbit polyclonal antibody against RFX5. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human RFX5
- Top Product
- Discover our top product RFX5 Primärantikörper
-
-
- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
-
Antigen size: 616 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- RFX5 (Regulatory Factor X 5 (RFX5))
- Andere Bezeichnung
- RFX5 (RFX5 Produkte)
- Synonyme
- regulatory factor X5 antikoerper, regulatory factor X, 5 (influences HLA class II expression) antikoerper, RFX5 antikoerper, Rfx5 antikoerper
- Hintergrund
-
RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. RFX is a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX.A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS, MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX.A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS, MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
Protein Interaction Partner: UBC, MRPL53, SLIRP, SRPRB, CDV3, LSM7, RPS19, RBMS1, NDUFA7, NDUFA2, ANKRA2, RFXANK, MLLT1, HDAC4, CIITA, HDAC2, RFXAP,
Protein Size: 616 - Molekulargewicht
- 68 kDa
- Gen-ID
- 5993
- NCBI Accession
- NM_001025603, NP_001020774
- UniProt
- P48382
-