NMRAL1 Antikörper (N-Term)

Produktnummer ABIN2780056

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NMRAL1 in WB. Es zeigt Reaktivität gegenüber Proben von Ratte, Maus, Rind (Kuh), Hund und Schwein.

Kurzübersicht für NMRAL1 Antikörper (N-Term) (ABIN2780056)

Target: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Reaktivität: Ratte, Maus, Rind (Kuh), Hund, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NMRAL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NMRAL1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: Nmral1 Antibody - N-terminal region

Sequenz: GATGAQGGSV ARALLEDGTF RIRVVTRNPE QRAAKELKQQ GAEVVRGDQD

Homologie: Cow: 79%, Dog: 79%, Mouse: 100%, Pig: 86%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against Nmral1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the n terminal region of mouse Nmral1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP37361-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu NMRAL1

Target: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Andere Bezeichnung: Nmral1

Hintergrund:

Background Information: Nmral1 is a redox sensor protein. Nmral1 undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP+ levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH.Nmral1 has higher affinity for NADPH than for NADP+. Binding to NADPH is necessary to form a stable dimer.

Gene Name: NmrA-like family domain containing 1

Alternative Symbols: AI256624, 1110025F24Rik

Protein Name: NmrA-like family domain-containing protein 1

Molekulargewicht: 34kDa

Gen-ID: 67824

NCBI Accession: NP_080669

UniProt: Q8K2T1