DNMT1 Antikörper (N-Term)

Produktnummer ABIN2779926

Der Kaninchen Polyklonal Anti-DNMT1-Antikörper wurde für WB validiert. Er ist geeignet, DNMT1 in Proben von Maus zu detektieren.

Kurzübersicht für DNMT1 Antikörper (N-Term) (ABIN2779926)

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNMT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DNMT1 Antikörper

Bindungsspezifität: N-Term

Sequenz: SSVATRRTTR QTTITAHFTK GPTKRKPKEE SEEGNSAESA AEERDQDKKR

Homologie: Mouse: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against Dnmt1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of mouse Dnmt1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Antigen size: 1619 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DNMT1

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Andere Bezeichnung: Dnmt1

Hintergrund: Dnmt1 methylates CpG residues.Dnmt1 preferentially methylates hemimethylated DNA. Dnmt1 associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance.Dnmt1 associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones.Dnmt1 mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, Dnmt1 is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Alias Symbols: Cxxc9, Dnmt, Dnmt1o, MTase, Met-1, Met1, MommeD2, MCMT, m.MmuI
Protein Interaction Partner: Uhrf1, Parp1, Eed, hist1h3g, DSK2, VPS9, Kat5, Ubc, Atm, NUB1, UBQLN1, SQSTM1, PSMD4, NBR1, RAD23B, Hesx1, Ezh2, Zbtb16, Cul3, Cdh1, Dmap1, Tcf3, hist1h4a, hist1h2bj, hist2h2ab, Dnmt1, Kcnq1ot1, Pla2g2a, Apc, Tox3, Rela, HDAC1,
Protein Size: 1619

Molekulargewicht: 183 kDa

Gen-ID: 13433

NCBI Accession: NM_010066, NP_034196

UniProt: P13864

Pathways: SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion