MDC1 Antikörper (C-Term)

Produktnummer ABIN2779807

Der Kaninchen Polyklonal anti-MDC1 Antikörper wird verwendet zum Nachweis von MDC1 in Proben von Human, Hund und Meerschweinchen. Er wurde validiert für WB.

Kurzübersicht für MDC1 Antikörper (C-Term) (ABIN2779807)

Target: MDC1 (Mdc1 (MDC1))

Reaktivität: Human, Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MDC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MDC1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: MDC1 Antibody - C-terminal region

Sequenz: GKEEDVVTPK PGKRKRDQAE EEPNRIPSRS LRRTKLNQES TAPKVLFTGV

Homologie: Dog: 86%, Guinea Pig: 92%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MDC1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MDC1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36798-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu MDC1

Target: MDC1 (Mdc1 (MDC1))

Andere Bezeichnung: MDC1

Hintergrund:

Background Information: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

Gene Name: Mediator of DNA-damage checkpoint 1

Alternative Symbols: NFBD1

Protein Name: Mediator of DNA damage checkpoint protein 1

Molekulargewicht: 227kDa

Gen-ID: 9656

NCBI Accession: NP_055456

UniProt: Q14676