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AIRE Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-AIRE-Antikörper wurde für WB validiert. Er ist geeignet, AIRE in Proben von Human, Ratte, Hund, Pferd, Rind (Kuh) und Schwein zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN2779776

Kurzübersicht für AIRE Antikörper (N-Term) (ABIN2779776)

Target

Alle AIRE Antikörper anzeigen
AIRE (Autoimmune Regulator (AIRE))

Reaktivität

  • 54
  • 26
  • 6
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
Human, Ratte, Hund, Pferd, Rind (Kuh), Schwein

Wirt

  • 50
  • 7
  • 1
  • 1
Kaninchen

Klonalität

  • 57
  • 1
Polyklonal

Konjugat

  • 43
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser AIRE Antikörper ist unkonjugiert

Applikation

  • 44
  • 27
  • 20
  • 14
  • 12
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 10
    • 9
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Sequenz

    DFWRVLFKDY NLERYGRLQP ILDSFPKDVD LSQPRKGRKP PAVPKALVPP

    Homologie

    Cow: 79%, Dog: 92%, Horse: 86%, Human: 100%, Pig: 93%, Rat: 79%

    Produktmerkmale

    This is a rabbit polyclonal antibody against AIRE. It was validated on Western Blot using a cell lysate as a positive control.

    Aufreinigung

    Protein A purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 545 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tao, Kupfer, Stewart, Williams-Skipp, Crowell, Patel, Sain, Scheinman: "AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix." in: Molecular immunology, Vol. 43, Issue 4, pp. 335-45, (2005) (PubMed).

  • Target

    AIRE (Autoimmune Regulator (AIRE))

    Andere Bezeichnung

    AIRE

    Hintergrund

    AIRE is a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
    Alias Symbols: APS1, APSI, PGA1, AIRE1, APECED
    Protein Interaction Partner: TUBB, RAVER1, TUBA1C, TMPRSS13, CCDC87, FAT1, GIGYF2, SRRM2, TUBB4B, EIF4EBP3, UBB, HSP90AB1, HSPA8, HSPA5, HSPA1L, HSPA1A, ATP4A, HIST3H3, HDAC2, HDAC1, DAXX, AIRE, UBAC1, HIST1H3A, HIST2H2BE, HSPA4, SRSF1, SMC1A, XPO1, TOP2A, SSRP1, SNRPD3, SNRPB, SRSF3
    Protein Size: 545

    Molekulargewicht

    58 kDa

    Gen-ID

    326

    NCBI Accession

    NM_000383, NP_000374

    UniProt

    O43918

    Pathways

    Chromatin Binding
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