AIRE Antikörper (N-Term)

Produktnummer ABIN2779776

Produktdetails anti-AIRE Antikörper

Target: AIRE (Autoimmune Regulator (AIRE))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Hund, Pferd, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AIRE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DFWRVLFKDY NLERYGRLQP ILDSFPKDVD LSQPRKGRKP PAVPKALVPP

Homologie: Cow: 79%, Dog: 92%, Horse: 86%, Human: 100%, Pig: 93%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against AIRE. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 545 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-AIRE Antikörper (ABIN2779776)

Tao, Kupfer, Stewart, Williams-Skipp, Crowell, Patel, Sain, Scheinman: "AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix." in: Molecular immunology, Vol. 43, Issue 4, pp. 335-45, (2005) (PubMed).

Details zu AIRE

Target: AIRE (Autoimmune Regulator (AIRE))

Andere Bezeichnung: AIRE (AIRE Produkte)

Hintergrund: AIRE is a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Alias Symbols: APS1, APSI, PGA1, AIRE1, APECED
Protein Interaction Partner: TUBB, RAVER1, TUBA1C, TMPRSS13, CCDC87, FAT1, GIGYF2, SRRM2, TUBB4B, EIF4EBP3, UBB, HSP90AB1, HSPA8, HSPA5, HSPA1L, HSPA1A, ATP4A, HIST3H3, HDAC2, HDAC1, DAXX, AIRE, UBAC1, HIST1H3A, HIST2H2BE, HSPA4, SRSF1, SMC1A, XPO1, TOP2A, SSRP1, SNRPD3, SNRPB, SRSF3
Protein Size: 545

Molekulargewicht: 58 kDa

Gen-ID: 326

NCBI Accession: NM_000383, NP_000374

UniProt: O43918

Pathways: Chromatin Binding