FOXP1 Antikörper (N-Term)

Produktnummer ABIN2779725

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FOXP1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Pferd und Meerschweinchen und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für FOXP1 Antikörper (N-Term) (ABIN2779725)

Target: FOXP1 (Forkhead Box P1 (FOXP1))

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-FOXP1 Antikörper

Bindungsspezifität: N-Term

Sequenz: MIPTELQQLW KEVTSAHTAE ETTGNNHSSL DLTTTCVSSS APSKTSLI

Homologie: Cow: 92%, Dog: 85%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against FOXP1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FOXP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 677 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FOXP1 Antikörper (ABIN2779725)

Tang, Becanovic, Desplats, Spencer, Hill, Connolly, Masliah, Leavitt, Thomas: "Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease." in: Human molecular genetics, Vol. 21, Issue 14, pp. 3097-111, (2012) (PubMed).

Konstantoulas, Parmar, Li: "FoxP1 promotes midbrain identity in embryonic stem cell-derived dopamine neurons by regulating Pitx3." in: Journal of neurochemistry, Vol. 113, Issue 4, pp. 836-47, (2010) (PubMed).

Jepsen, Gleiberman, Shi, Simon, Rosenfeld: "Cooperative regulation in development by SMRT and FOXP1." in: Genes & development, Vol. 22, Issue 6, pp. 740-5, (2008) (PubMed).

Details zu FOXP1

Target: FOXP1 (Forkhead Box P1 (FOXP1))

Andere Bezeichnung: FOXP1

Hintergrund: FOXP1 belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s).
Alias Symbols: QRF1, 12CC4, hFKH1B, HSPC215
Protein Interaction Partner: SUMO2, MYC, IL3RA, ELAVL1, NCOR2, GATAD2B, MTA1, FOXP1, FOXP4, FOXP2, CTBP1,
Protein Size: 677

Molekulargewicht: 75 kDa

Gen-ID: 27086

NCBI Accession: NM_032682, NP_116071

UniProt: Q9H334

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response