KAT2B Antikörper (N-Term)

Produktnummer ABIN2779660

Der Kaninchen Polyklonal Anti-KAT2B-Antikörper wurde für WB validiert. Er ist geeignet, KAT2B in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen und Zebrafisch (Danio rerio) zu detektieren.

Kurzübersicht für KAT2B Antikörper (N-Term) (ABIN2779660)

Target: KAT2B (K(lysine) Acetyltransferase 2B (KAT2B))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KAT2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KAT2B Antikörper

Bindungsspezifität: N-Term

Sequenz: LFKLLRKSIL QRGKPVVEGS LEKKPPFEKP SIEQGVNNFV QYKFSHLPAK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 90%

Produktmerkmale: This is a rabbit polyclonal antibody against PCAF. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCAF

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 832 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu KAT2B

Target: KAT2B (K(lysine) Acetyltransferase 2B (KAT2B))

Andere Bezeichnung: PCAF

Hintergrund: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. PCAF associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
Alias Symbols: P, CAF, PCAF, P/CAF
Protein Interaction Partner: MDM2, HNRNPD, ACLY, KLF2, E2F1, VHL, IRF1, TAL1, TAF12, TAF10, TAF9, TADA2A, RB1, HIST1H1B, TAF5L, TAF6L, TADA3, SUPT3H, TWIST1, PDK1, AKT1, UBC, SIAH2, UBE2D3, UBE2D1, TP73, TP53, SRC, PGR, YEATS2, MBIP, WDR5, PTEN, DR1, HIF1A, HIST2H3C, CHEK2, HIST1H4A,
Protein Size: 832

Molekulargewicht: 93 kDa

Gen-ID: 8850

NCBI Accession: NM_003884, NP_003875

UniProt: Q92831

Pathways: p53 Signalweg, Regulation of Carbohydrate Metabolic Process