NCOR2 Antikörper (N-Term)

Produktnummer ABIN2779658

Dieses Anti-NCOR2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von NCOR2 in WB. Geeignet für Human, Maus, Ratte, Schwein, Rind (Kuh), Hund, Zebrafisch (Danio rerio) und Saccharomyces cerevisiae.

Kurzübersicht für NCOR2 Antikörper (N-Term) (ABIN2779658)

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCOR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NCOR2 Antikörper

Bindungsspezifität: N-Term

Sequenz: PMPRSSQEEK DEKEKEKEAE KEEEKPEVEN DKEDLLKEKT DDTSGEDNDE

Homologie: Cow: 93%, Dog: 86%, Human: 100%, Mouse: 86%, Pig: 100%, Rat: 86%, Yeast: 87%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against NCOR2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NCOR2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 2524 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NCOR2

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Andere Bezeichnung: NCOR2

Hintergrund: NCOR2 forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.
Alias Symbols: SMRT, TRAC, CTG26, SMRTE, TRAC1, N-CoR2, TNRC14, TRAC-1, SMAP270, SMRTE-tau
Protein Interaction Partner: HDAC4, HDAC3, RARA, HMGA1, HDAC2, HDAC1, AURKA, BCL6, BCOR, GPS2, ZBTB16, UBC, E2F1, NR1I2, BTRC, HDAC7, NR1H2, THRA, RUNX1, Pparg, Nr2f1, Nr1i3, Nr2f2, CBX6, C1D, NR1H4, NR1D1, Ppard, SUMO2, CTBP1, ARNT, AHR, NCOR1, AR, NRD1, E2F4, ZBTB7A, SOX2, ESR1, CE
Protein Size: 2524

Molekulargewicht: 275 kDa

Gen-ID: 9612

NCBI Accession: NM_006312, NP_006303

UniProt: Q9Y618

Pathways: Notch Signalweg, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha