SIRT3 Antikörper (C-Term)

Produktnummer ABIN2779610

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SIRT3 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Kaninchen, Meerschweinchen, Pferd und Rind (Kuh) und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für SIRT3 Antikörper (C-Term) (ABIN2779610)

Target: SIRT3 (Sirtuin 3 (SIRT3))

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Meerschweinchen, Pferd, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SIRT3 Antikörper

Bindungsspezifität: C-Term

Sequenz: VGPLAWHPRS RDVAQLGDVV HGVESLVELL GWTEEMRDLV QRETGKLDGP

Homologie: Cow: 100%, Dog: 79%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against SIRT3. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SIRT3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 257 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SIRT3 Antikörper (ABIN2779610)

Vidimar, Gius, Chakravarti, Bulun, Wei, Kim: "Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas." in: Science advances, Vol. 2, Issue 11, pp. e1601132, (2016) (PubMed).

Marfè, Tafani, Fiorito, Pagnini, Iovane, De Martino: "Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis." in: PLoS ONE, Vol. 6, Issue 11, pp. e27313, (2011) (PubMed).

Lanza, Short, Short, Raghavakaimal, Basu, Joyner, McConnell, Nair: "Endurance exercise as a countermeasure for aging." in: Diabetes, Vol. 57, Issue 11, pp. 2933-42, (2008) (PubMed).

Details zu SIRT3

Target: SIRT3 (Sirtuin 3 (SIRT3))

Andere Bezeichnung: SIRT3

Hintergrund: The SIRT3 gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT3 encodes a protein that is included in class I of the sirtuin family.
Alias Symbols: SIR2L3
Protein Interaction Partner: SIRT5, SKP2, UBC, HSPD1, CMYA5, PGAP1, RIF1, NCAPD2, HERC2, TTF2, UQCRH, UGDH, HSP90B1, SNTB1, SBF1, HSPA9, HSPA5, HSPA4, HSPA1L, GRN, ATP5B, ATP5A1, SIRT4, tat, XRCC6, FOXO3, DNM1L, PEX5,
Protein Size: 257

Molekulargewicht: 28 kDa

Gen-ID: 23410

NCBI Accession: NM_001017524, NP_001017524

UniProt: Q9NTG7