SIRT2 Antikörper (N-Term)

Produktnummer ABIN2779604

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SIRT2 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus, Kaninchen, Hund, Meerschweinchen, Rind (Kuh), Schwein, Pferd und Saccharomyces cerevisiae und wurde in 1 Publikation erwähnt.

Kurzübersicht für SIRT2 Antikörper (N-Term) (ABIN2779604)

Target: SIRT2 (Sirtuin 2 (SIRT2))

Reaktivität: Human, Ratte, Maus, Kaninchen, Hund, Meerschweinchen, Rind (Kuh), Schwein, Pferd, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SIRT2 Antikörper

Bindungsspezifität: N-Term

Sequenz: MAEPDPSHPL ETQAGKVQEA QDSDSDSEGG AAGGEADMDF LRNLFSQTLS

Homologie: Cow: 92%, Dog: 82%, Guinea Pig: 85%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 100%, Rat: 77%, Yeast: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against SIRT2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SIRT2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 389 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SIRT2 Antikörper (ABIN2779604)

Benavente, Schnell, Jacobson: "Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin." in: PLoS ONE, Vol. 7, Issue 7, pp. e42276, (2012) (PubMed).

Details zu SIRT2

Target: SIRT2 (Sirtuin 2 (SIRT2))

Andere Bezeichnung: SIRT2

Hintergrund: SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by SIRT2 is included in class I of the sirtuin family.
Alias Symbols: SIR2, SIR2L, SIR2L2
Protein Interaction Partner: ACLY, SIRT1, UBC, ING1, EP300, CBLB, CBL, XPO1, CDC20, FZR1, RUNX3, PCK1, FOXO1, HDAC6, tat, RBP1, HIST1H3A, NUDT21, PAPOLA, DNAJB8, DNAJB6, SP140, KAT2B, CDC14B, KAT2A, TUBA4A, HOXA10, TUBB, KRT78, RTN4, PHB2, SPOP, ELL, SARS, GYS1,
Protein Size: 389

Molekulargewicht: 43 kDa

Gen-ID: 22933

NCBI Accession: NM_012237, NP_036369

UniProt: Q8IXJ6