ETV4 Antikörper (Middle Region)

Produktnummer ABIN182518

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch ETV4 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Pferd und Kaninchen und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für ETV4 Antikörper (Middle Region) (ABIN182518)

Target: ETV4 (Ets Variant 4 (ETV4))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ETV4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ETV4 Antikörper

Bindungsspezifität: Middle Region

Sequenz: HSSVFQQPLD ICHSFTSQGG GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH

Homologie: Cow: 100%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ETV4. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ETV4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 484 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ETV4 Antikörper (ABIN182518)

Kedage, Selvaraj, Nicholas, Budka, Plotnik, Jerde, Hollenhorst: "An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer." in: Cell reports, Vol. 17, Issue 5, pp. 1289-1301, (2016) (PubMed).

Okimoto, Breitenbuecher, Olivas, Wu, Gini, Hofree, Asthana, Hrustanovic, Flanagan, Tulpule, Blakely, Haringsma, Simmons, Gowen, Suh, Miller, Ali, Schuler, Bivona: "Inactivation of Capicua drives cancer metastasis." in: Nature genetics, Vol. 49, Issue 1, pp. 87-96, (2016) (PubMed).

Selvaraj, Budka, Ferris, Jerde, Hollenhorst: "Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation." in: Molecular cancer, Vol. 13, pp. 61, (2014) (PubMed).

Hollenhorst, Paul, Ferris, Graves: "The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells." in: Genes & cancer, Vol. 1, Issue 10, pp. 1044-1052, (2011) (PubMed).

Hollenhorst, Ferris, Hull, Chae, Kim, Graves: "Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells." in: Genes & development, Vol. 25, Issue 20, pp. 2147-57, (2011) (PubMed).

Details zu ETV4

Target: ETV4 (Ets Variant 4 (ETV4))

Andere Bezeichnung: ETV4

Hintergrund: The protein encoded by the ETV4 gene is known to play a role in ovarian and breast malignancies as well as in the early stage of colorectal carcinogenesis.
Alias Symbols: E1A-F, E1AF, PEA3, PEAS3
Protein Interaction Partner: STK11, RFWD2, TP63, ATXN1, HTT, APP, UBC, SMAD2, SUMO2, SUMO1, SAE1, UBA2, HOXD4, EP300, SRF,
Protein Size: 484

Molekulargewicht: 54 kDa

Gen-ID: 2118

NCBI Accession: NM_001986, NP_001977

UniProt: P43268