ETV4 Antikörper (Middle Region)

Produktnummer ABIN2779533

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ETV4 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Pferd und Kaninchen und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für ETV4 Antikörper (Middle Region) (ABIN2779533)

Target: ETV4 (Ets Variant 4 (ETV4))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ETV4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ETV4 Antikörper

Bindungsspezifität: Middle Region

Sequenz: HSSVFQQPLD ICHSFTSQGG GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH

Homologie: Cow: 100%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ETV4. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ETV4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 484 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ETV4 Antikörper (ABIN2779533)

Kedage, Selvaraj, Nicholas, Budka, Plotnik, Jerde, Hollenhorst: "An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer." in: Cell reports, Vol. 17, Issue 5, pp. 1289-1301, (2016) (PubMed).

Okimoto, Breitenbuecher, Olivas, Wu, Gini, Hofree, Asthana, Hrustanovic, Flanagan, Tulpule, Blakely, Haringsma, Simmons, Gowen, Suh, Miller, Ali, Schuler, Bivona: "Inactivation of Capicua drives cancer metastasis." in: Nature genetics, Vol. 49, Issue 1, pp. 87-96, (2016) (PubMed).

Selvaraj, Budka, Ferris, Jerde, Hollenhorst: "Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation." in: Molecular cancer, Vol. 13, pp. 61, (2014) (PubMed).

Hollenhorst, Paul, Ferris, Graves: "The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells." in: Genes & cancer, Vol. 1, Issue 10, pp. 1044-1052, (2011) (PubMed).

Hollenhorst, Ferris, Hull, Chae, Kim, Graves: "Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells." in: Genes & development, Vol. 25, Issue 20, pp. 2147-57, (2011) (PubMed).

Details zu ETV4

Target: ETV4 (Ets Variant 4 (ETV4))

Andere Bezeichnung: ETV4

Hintergrund: The protein encoded by the ETV4 gene is known to play a role in ovarian and breast malignancies as well as in the early stage of colorectal carcinogenesis.
Alias Symbols: E1A-F, E1AF, PEA3, PEAS3
Protein Interaction Partner: STK11, RFWD2, TP63, ATXN1, HTT, APP, UBC, SMAD2, SUMO2, SUMO1, SAE1, UBA2, HOXD4, EP300, SRF,
Protein Size: 484

Molekulargewicht: 54 kDa

Gen-ID: 2118

NCBI Accession: NM_001986, NP_001977

UniProt: P43268