SMAD7 Antikörper (N-Term)

Produktnummer ABIN2779418

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-SMAD7 Antikörper (ABIN2779418) detektiert spezifisch SMAD7 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh), Hund, Schwein und Kaninchen.

Kurzübersicht für SMAD7 Antikörper (N-Term) (ABIN2779418)

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SMAD7 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: SMAD7 Antibody - N-terminal region

Sequenz: LVRRLWRSRA PGGEDEEEGA GGGGGGGELR GEGATDSRAH GAGGGGPGRA

Homologie: Cow: 93%, Dog: 93%, Human: 100%, Mouse: 92%, Pig: 93%, Rabbit: 93%, Rat: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against SMAD7. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD7

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8111905

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SMAD7 Antikörper (ABIN2779418)

Briones-Orta, Sosa-Garrocho, Moreno-Alvarez, Fonseca-Sánchez, Macías-Silva: "SnoN co-repressor binds and represses smad7 gene promoter." in: Biochemical and biophysical research communications, Vol. 341, Issue 3, pp. 889-94, (2006) (PubMed).

Details zu SMAD7

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Andere Bezeichnung: SMAD7

Hintergrund:

Background Information: Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition.

Gene Name: SMAD family member 7

Alternative Symbols: CRCS3, MADH7, MADH8

Protein Name: Mothers against decapentaplegic homolog 7

Molekulargewicht: 46kDa

Gen-ID: 4092

NCBI Accession: NP_005895

UniProt: O15105

Pathways: Interferon-gamma Pathway, Cell-Cell Junction Organization