IDE Antikörper (N-Term)

Produktnummer ABIN2779367

Der Kaninchen Polyklonal anti-IDE Antikörper (ABIN2779367) detektiert spezifisch IDE in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Zebrafisch (Danio rerio), Kaninchen, Meerschweinchen und Schwein.

Kurzübersicht für IDE Antikörper (N-Term) (ABIN2779367)

Target: IDE (Insulin-Degrading Enzyme (IDE))

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Zebrafisch (Danio rerio), Kaninchen, Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IDE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IDE Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: IDE Antibody - N-terminal region

Sequenz: LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against IDE. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP30652-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu IDE

Target: IDE (Insulin-Degrading Enzyme (IDE))

Andere Bezeichnung: IDE

Hintergrund:

Background Information: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.

Gene Name: Insulin-degrading enzyme

Alternative Symbols: INSULYSIN

Protein Name: Insulin-degrading enzyme

Molekulargewicht: 118kDa

Gen-ID: 3416

NCBI Accession: NP_004960

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interaktom